Non-enzymatic nitric oxide synthesis in biological systems
نویسندگان
چکیده
منابع مشابه
Non-nitric oxide based metallovasodilators: synthesis, reactivity and biological studies.
There is an increasing number of compounds developed to target one or more pathways involved in vasodilation. Some studies conducted with azaindole and indazole derivatives showed cardiovascular activity associated with these compounds. Fast and easy structural modification of these organic molecules can be achieved using metal complexes promoting a much larger spatial change than organic strat...
متن کاملNitric oxide and superoxide in biological systems
The chemistry of peroxynitrite is complex and highly pHdependent [6,7]. Not only peroxynitrite anion (ONOO-) and its conjugated acid, peroxynitrous acid (ONOOH) (pKa = 6.8) are potent oxidants by themselves [8,9] but also they can lead to the production of secondary reactive species. Moreover, peroxynitrite is capable of nitrating aromatics [10] in a process that can be enhanced by metal centre...
متن کاملNitric oxide and superoxide in biological systems
DETC: diethyldithiocarbamate, DMPO: 5,5-dimethyl-1-pyrroline N-oxide, DNIC: di-nitrosyl-iron complex, DTCS: N-(dithiocarboxy)sarcosine, EDRF: endothelium-derived relaxing factor, EPR, ESR: electron paramagnetic resonance; electron spin resonance, cGMP: cyclic GMP, Hb: hemoglobin, LPS: lipopolysaccharide, Mb: myoglobin, MGD: N-methyl-D-glucamine dithiocarbamate, MNIC: mono-nitrosyl-iron complex,...
متن کاملNitric oxide and superoxide in biological systems
Oxygen-derived free radicals play a major role in the physiology and pathology of the vessel wall [1]. To assess superoxide anion production (O2) from endothelium, four techniques are mainly used: reduced cytochrome c UV-visible absorption [2,3], ESR spin trapping [4,5], hydroethydine fluorescence [6] and lucigenin-enhanced chemiluminescence [7,8]. The simplest technique which has been used for...
متن کاملNitric oxide and superoxide in biological systems
The measurement of nitric oxide (NO) is important for direct examination of the regulatory roles of this radical in various biological systems. Nitric oxide production indeed participates in the control of major cell functions including reactivity, proliferation and apoptosis. An inappropriate production or metabolism of this radical led to the development of various pathologies, including card...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Bioenergetics
سال: 1999
ISSN: 0005-2728
DOI: 10.1016/s0005-2728(99)00018-3